Transient anomalous diffusion of telomeres in the nucleus of mammalian cells

I. Bronstein*, Y. Israel, E. Kepten, S. Mai, Y. Shav-Tal, E. Barkai, Y. Garini

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We measured individual trajectories of fluorescently labeled telomeres in the nucleus of eukaryotic cells in the time range of 10-2-104sec by combining a few acquisition methods. At short times the motion is subdiffusive with r2∼tα and it changes to normal diffusion at longer times. The short times diffusion may be explained by the reptation model and the transient diffusion is consistent with a model of telomeres that are subject to a local binding mechanism with a wide but finite distribution of waiting times. These findings have important biological implications with respect to the genome organization in the nucleus.

Original languageEnglish
Article number018102
JournalPhysical Review Letters
Volume103
Issue number1
DOIs
StatePublished - 6 Aug 2009
Externally publishedYes

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