Transgenic organisms expressing genes from Bacillus thuringiensis to combat insect pests

Arieh Zaritsky*, Eitan Ben-Dov, Dov Borovsky, Sammy Boussiba, Monica Einav, Galina Gindin, A. Rami Horowitz, Mikhail Kolot, Olga Melnikov, Zvi Mendel, Ezra Yagil

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Various subspecies (ssp.) of Bacillus thuringiensis (Bt) are considered the best agents known so far to control insects, being highly specific and safe, easily mass produced and with long shelf life.1 The para-cryst lline body that is produced during sporulation I the exosporium includes polypeptides named δ-endotoxins, each killing a specific set of insects. The different entomopathogenic toxins of various Bt ssp. can be manipulated genetically in an educated way to construct more efficient transgenic bacteria or plants that express combinations of toxin genes to control pests.2 Joint research projects in our respective laboratories during the last decade demonstrate what can be done by implementing certain ideas using molecular biology with Bt ssp. israelensis (Bti) as a model system. Here, we describe our progress achieved with Gram-negative bacterial species, including cyanobacteria, and some preliminary experiments to form transgenic plants, mainly to control mosquitoes (Diptera), but also a particular Lepidopteran and Coleopteran pest species. In addition, a system is described by which environment-damaging genes can be removed from the recombinants thus alleviating procedures for obtaining permits to release them in nature.

Original languageEnglish
Pages (from-to)341-344
Number of pages4
JournalBioengineered Bugs
Issue number5
StatePublished - 2010


FundersFunder number
Israel Ministry of Agriculture131-1481-09
Israel Ministry of Science, Jerusalem82606101
United States-Israel Binational Science Foundation2003-394, 2001-042, 2007-037


    • Bacillus thuringiensis
    • Control of insect pest larvae
    • Environmental considerations
    • Recombinant organisms
    • Synergy
    • δ-endotoxins


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