Abstract
Heterocyclic benzotriazine N-oxides are an interesting class of experimental anticancer and antibacterial agents. Analogs with 18O incorporated into the N-oxide group may offer useful mechanistic tools. We describe the use of H 2 18OF·CH 3CN in a fast, readily executed and high-yielding preparation of 1,2,4-benzotriazine 1,4-dioxides containing an 18O-label at the 4-oxide position.
Original language | English |
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Pages (from-to) | 8942-8944 |
Number of pages | 3 |
Journal | Tetrahedron |
Volume | 68 |
Issue number | 43 |
DOIs | |
State | Published - 28 Oct 2012 |
Keywords
- F /N
- H O
- HOF·CH CN
- N-oxide
- O isotope
- Oxygen transfer
- Tirapazamine