Transferring oxygen isotopes to 1,2,4-benzotriazine 1-oxides forming the corresponding 1,4-dioxides by using the HOF·CH 3CN complex

Julia Gatenyo, Kevin Johnson, Anuruddha Rajapakse, Kent S. Gates, Shlomo Rozen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Heterocyclic benzotriazine N-oxides are an interesting class of experimental anticancer and antibacterial agents. Analogs with 18O incorporated into the N-oxide group may offer useful mechanistic tools. We describe the use of H 2 18OF·CH 3CN in a fast, readily executed and high-yielding preparation of 1,2,4-benzotriazine 1,4-dioxides containing an 18O-label at the 4-oxide position.

Original languageEnglish
Pages (from-to)8942-8944
Number of pages3
JournalTetrahedron
Volume68
Issue number43
DOIs
StatePublished - 28 Oct 2012

Keywords

  • F /N
  • H O
  • HOF·CH CN
  • N-oxide
  • O isotope
  • Oxygen transfer
  • Tirapazamine

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