Transepithelial intestinal excretion of ciprofloxacin in humans

Jacob Ramon, Menachem Ben-Haim, Moshe Shabtai, Ethan Rubinstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The excretion of ciprofloxacin in the small bowel was studied in 40 patients undergoing bowel surgery. Ciprofloxacin (200 mg) was administered iv, and intestinal samples were collected over a 120-min period. In ileal loops ciprofloxacin concentrations reached a peak of 4.0 mg/L, whereas in caecal fluid samples, concentrations were <0.16 mg/L. Ciprofloxacin administered directly into the ileal and caecal loops did not result in measurable blood levels for 2 h. The results confirm that ciprofloxacin is selectively excreted into the small bowel.

Original languageEnglish
Pages (from-to)822-823
Number of pages2
JournalClinical Infectious Diseases
Issue number5
StatePublished - 1 Mar 2001
Externally publishedYes


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