TY - JOUR
T1 - Transduplication resulted in the incorporation of two protein-coding sequences into the Turmoil-1 transposable element of C. elegans
AU - Sela, Noa
AU - Stern, Adi
AU - Makalowski, Wojciech
AU - Pupko, Tal
AU - Ast, Gil
N1 - Funding Information:
We thank Prof. Jerzy Jurka for critical reading of the manuscript. This work was supported by the Israeli Ministry of Science and Technology (MOST) and by grants from the Israel Science Foundation (1449/04 and 40/05), MOP Germany-Israel, GIF, ICA through the Ber-Lehmsdorf Memorial Fund, and DIP and EURASNET. AS is a fellow of the Complexity Science Scholarship program and is supported by a fellowship from the Israeli Ministry of Science.
PY - 2008/10/8
Y1 - 2008/10/8
N2 - Transposable elements may acquire unrelated gene fragments into their sequences in a process called transduplication. Transduplication of protein-coding genes is common in plants, but is unknown of in animals. Here, we report that the Turmoil-1 transposable element in C. elegans has incorporated two protein-coding sequences into its inverted terminal repeat (ITR) sequences. The ITRs of Turmoil-1 contain a conserved RNA recognition motif (RRM) that originated from the rsp-2 gene and a fragment from the protein-coding region of the cpg-3 gene. We further report that an open reading frame specific to C. elegans may have been created as a result of a Turmoil-1 insertion. Mutations at the 5′ splice site of this open reading frame may have reactivated the transduplicated RRM motif.
AB - Transposable elements may acquire unrelated gene fragments into their sequences in a process called transduplication. Transduplication of protein-coding genes is common in plants, but is unknown of in animals. Here, we report that the Turmoil-1 transposable element in C. elegans has incorporated two protein-coding sequences into its inverted terminal repeat (ITR) sequences. The ITRs of Turmoil-1 contain a conserved RNA recognition motif (RRM) that originated from the rsp-2 gene and a fragment from the protein-coding region of the cpg-3 gene. We further report that an open reading frame specific to C. elegans may have been created as a result of a Turmoil-1 insertion. Mutations at the 5′ splice site of this open reading frame may have reactivated the transduplicated RRM motif.
UR - http://www.scopus.com/inward/record.url?scp=54949125357&partnerID=8YFLogxK
U2 - 10.1186/1745-6150-3-41
DO - 10.1186/1745-6150-3-41
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AN - SCOPUS:54949125357
SN - 1745-6150
VL - 3
JO - Biology Direct
JF - Biology Direct
M1 - 41
ER -