TY - JOUR
T1 - Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer
AU - Sarfstein, Rive
AU - Maor, Sharon
AU - Reizner, Naama
AU - Abramovitch, Shirley
AU - Werner, Haim
N1 - Funding Information:
Work in the laboratory of H.W. is supported by grants from the U.S.-Israel Binational Science Foundation and the Cooperation Program in Cancer Research of the Deutsches Krebsforschungszentrum (DKFZ) and Israel's Ministry of Science and Technology.
PY - 2006/6/27
Y1 - 2006/6/27
N2 - The insulin-like growth factor-I receptor (IGF-IR) has an important role in normal mammary gland growth and morphogenesis. In addition, the IGF-IR has been implicated in the initiation and progression of breast cancer. Previous studies have indicated that acquisition of the malignant phenotype in breast cancer is initially IGF-IR dependent. Most breast cancer-derived cell lines and primary tumors express high levels of IGF-IR mRNA and protein, whereas metastatic stages are usually associated with a decrease in IGF-IR levels. Transcription of the IGF-IR gene is controlled by complex interactions involving DNA-binding and non DNA-binding transcription factors. This review highlights selected examples of tumor suppressors, including BRCA1, p53, and WT1, whose mechanism of action involves regulation of IGF-IR gene expression.
AB - The insulin-like growth factor-I receptor (IGF-IR) has an important role in normal mammary gland growth and morphogenesis. In addition, the IGF-IR has been implicated in the initiation and progression of breast cancer. Previous studies have indicated that acquisition of the malignant phenotype in breast cancer is initially IGF-IR dependent. Most breast cancer-derived cell lines and primary tumors express high levels of IGF-IR mRNA and protein, whereas metastatic stages are usually associated with a decrease in IGF-IR levels. Transcription of the IGF-IR gene is controlled by complex interactions involving DNA-binding and non DNA-binding transcription factors. This review highlights selected examples of tumor suppressors, including BRCA1, p53, and WT1, whose mechanism of action involves regulation of IGF-IR gene expression.
KW - BRCA1
KW - Breast cancer
KW - IGF-IR
KW - Transcription factors
KW - WT1
KW - p53
UR - http://www.scopus.com/inward/record.url?scp=33745211914&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2006.03.018
DO - 10.1016/j.mce.2006.03.018
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AN - SCOPUS:33745211914
SN - 0303-7207
VL - 252
SP - 241
EP - 246
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 1-2
ER -
