Transcription in the nucleus and mRNA decay in the cytoplasm are coupled processes

Vicky Goler-Baron, Michael Selitrennik, Oren Barkai, Gal Haimovich, Rona Lotan, Mordechai Choder*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Maintaining appropriate mRNAs levels is vital for any living cell. mRNA synthesis in the nucleus by RNA polymerase II core enzyme (Pol II) and mRNA decay by cytoplasmic machineries determine these levels. Yet, little is known about possible cross-talk between these processes. The yeast Rpb4/7 is a nucleo-cytoplasmic shuttling heterodimer that interacts with Pol II and with mRNAs and is required for mRNA decay in the cytoplasm. Here we show that interaction of Rpb4/7 with mRNAs and eventual decay of these mRNAs in the cytoplasm depends on association of Rpb4/7 with Pol II in the nucleus. We propose that, following its interaction with Pol II, Rpb4/7 functions in transcription, interacts with the transcript cotranscriptionally and travels with it to the cytoplasm to stimulate mRNA decay. Hence, by recruiting Rpb4/7, Pol II governs not only transcription but also mRNA decay.

Original languageEnglish
Pages (from-to)2022-2027
Number of pages6
JournalGenes and Development
Issue number15
StatePublished - 1 Aug 2008
Externally publishedYes


  • RNA polymerase II
  • Yeast
  • mRNA decay


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