Transcranial application of low-energy laser irradiation improves neurological deficits in rats following acute stroke

Luis DeTaboada, Sanja Ilic, Sandra Leichliter-Martha, Uri Oron*, Amir Oron, Jackson Streeter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

141 Scopus citations

Abstract

Background and Objectives: Low-level laser therapy (LLLT) has been shown to have beneficial effects on ischemic skeletal and heart muscles tissues. The aim of the present study was to approve the effectiveness of LLLT treatment at different locations on the brain in acute stroked rats. Study Design/Materials and Methods: Stroke was induced in 169 rats that were divided into four groups: control non-laser and three laser-treated groups where laser was employed ipsilateral, contralateral, and both to the side of the induced stroke. Rats were tested for neurological function. Results: In all three laser-treated groups, a marked and significant improvement in neurological deficits was evident at 14, 21, and 28 days post stroke relative to the non-treated group. Conclusions: These observations suggest that LLLT applied at different locations in the skull and in a rather delayed-phase post stroke effectively improves neurological function after acute stroke in rats.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalLasers in Surgery and Medicine
Volume38
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Acute
  • Biostimulation
  • Laser
  • Rats
  • Stroke

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