TY - JOUR
T1 - Transcleral approach for closing retinal tears using DuraSeal™ hydrogel sealant
AU - Barliya, Tilda
AU - Sandalon, Shai
AU - Ofri, Ron
AU - Livnat, Tami
AU - Weinberger, Dov
N1 - Publisher Copyright:
© 2018 Indian Journal of Ophthalmology.
PY - 2018/2
Y1 - 2018/2
N2 - Purpose: The aim of this study was to evaluate an innovative approach for closing retinal tears using DuraSeal™ (DS) hydrogel sealant in a rabbit model. Methods: Retinal detachment with a small tear was performed on 20 New Zealand rabbits. Thereafter, rabbits were divided into two groups; the experimental group received a transscleral injection of 0.1 ml DS into the subretinal space whereas the control group received sham injection of saline. Eyes were clinically evaluated using indirect ophthalmoscopy, retinal function was recorded in ten rabbits by electroretinography and the sealant's toxicity was evaluated histopathologically. Results: We found that the DS hydrogel was easily injected transsclerally into the subretinal space of the detached retinas with no major complications. Retinal reattachment was seen in both groups within 2 weeks with no toxicity to the sensory retina. There were no significant differences in retinal function between groups. Conclusion: Subretinal injection of hydrogel through a transscleral route is easy to perform and may open a new avenue in the treatment of retinal detachment. However, the efficacy of the DS as a tamponade for sealing retinal tear is yet to be definite. Long-term clinical, functional, and toxicological studies are needed to evaluate its full potential for clinical applications.
AB - Purpose: The aim of this study was to evaluate an innovative approach for closing retinal tears using DuraSeal™ (DS) hydrogel sealant in a rabbit model. Methods: Retinal detachment with a small tear was performed on 20 New Zealand rabbits. Thereafter, rabbits were divided into two groups; the experimental group received a transscleral injection of 0.1 ml DS into the subretinal space whereas the control group received sham injection of saline. Eyes were clinically evaluated using indirect ophthalmoscopy, retinal function was recorded in ten rabbits by electroretinography and the sealant's toxicity was evaluated histopathologically. Results: We found that the DS hydrogel was easily injected transsclerally into the subretinal space of the detached retinas with no major complications. Retinal reattachment was seen in both groups within 2 weeks with no toxicity to the sensory retina. There were no significant differences in retinal function between groups. Conclusion: Subretinal injection of hydrogel through a transscleral route is easy to perform and may open a new avenue in the treatment of retinal detachment. However, the efficacy of the DS as a tamponade for sealing retinal tear is yet to be definite. Long-term clinical, functional, and toxicological studies are needed to evaluate its full potential for clinical applications.
KW - DuraSeal hydrogel sealant
KW - retinal detachment
KW - retinal tear
KW - transcleral approach
UR - http://www.scopus.com/inward/record.url?scp=85041620802&partnerID=8YFLogxK
U2 - 10.4103/ijo.IJO_758_17
DO - 10.4103/ijo.IJO_758_17
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AN - SCOPUS:85041620802
SN - 0301-4738
VL - 66
SP - 238
EP - 243
JO - Indian Journal of Ophthalmology
JF - Indian Journal of Ophthalmology
IS - 2
ER -