Transabdominal ultrasonographic evaluation of endometrial thickness in clomiphene citrate‐stimulated cycles in relation to conception

Igal Wolman*, Joseph Sagi, David Pauzner, Israel Yovel, Daniel S. Seidman, Menachem P. David

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The possible antiestrogenic effect of clomiphene citrate on endometrial growth was assessed by serial transabdominal ultrasonographic measurements in 46 women with unexplained infertility. A significantly higher (p < 0.05) rate of endometrial growth was observed in the 8 women who conceived compared with the 38 women who failed to conceive. A thicker endometrium (4.6 ± 0.3 mm) was observed from the third day before ovulation as well as a higher average growth rate in the three days prior to ovulation (0.7 ± 0.1 mm/day) in the group that achieved pregnancy compared to a lower endometrium (2.1 ± 0.2 mm) from the third day before ovulation and a slower growth rate in the three days prior to ovulation (0.2 ± 0.0 mm/day) in the group that did not achieve pregnancy (p < 0.05). These data suggest that clomiphene citrate may exert an antiestrogenic effect on the endometrium, and thus interfere with implantation. © 1994 John Wiley & Sons, Inc.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalJournal of Clinical Ultrasound
Volume22
Issue number2
DOIs
StatePublished - Feb 1994

Keywords

  • Endometrial thickness
  • Infertility
  • Menstrual cycles, stimulated

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