Trade-off between Transcriptome Plasticity and Genome Evolution in Cephalopods

Noa Liscovitch-Brauer, Shahar Alon, Hagit T. Porath, Boaz Elstein, Ron Unger, Tamar Ziv, Arie Admon, Erez Y. Levanon, Joshua J.C. Rosenthal*, Eli Eisenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

214 Scopus citations

Abstract

RNA editing, a post-transcriptional process, allows the diversification of proteomes beyond the genomic blueprint; however it is infrequently used among animals for this purpose. Recent reports suggesting increased levels of RNA editing in squids thus raise the question of the nature and effects of these events. We here show that RNA editing is particularly common in behaviorally sophisticated coleoid cephalopods, with tens of thousands of evolutionarily conserved sites. Editing is enriched in the nervous system, affecting molecules pertinent for excitability and neuronal morphology. The genomic sequence flanking editing sites is highly conserved, suggesting that the process confers a selective advantage. Due to the large number of sites, the surrounding conservation greatly reduces the number of mutations and genomic polymorphisms in protein-coding regions. This trade-off between genome evolution and transcriptome plasticity highlights the importance of RNA recoding as a strategy for diversifying proteins, particularly those associated with neural function.

Original languageEnglish
Pages (from-to)191-202.e11
JournalCell
Volume169
Issue number2
DOIs
StatePublished - 6 Apr 2017

Funding

FundersFunder number
National Institute of Neurological Disorders and StrokeR01NS064259

    Keywords

    • ADAR
    • Epitranscriptome
    • RNA editing
    • RNA modifications
    • cephalopods
    • genome evolution
    • neural plasticity
    • proteome diversity

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