Trabeculectomy with brief exposure to mitomycin C

Guy J. Ben Simon*, Yoseph Glovinsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: To evaluate the safety and efficacy of primary trabeculectomy with brief exposure (15 s) to mitomycin C (MMC) (0.4mg/mL). Methods: Medical record review of all patients who underwent primary trabeculectomy with brief exposure to MMC at the Goldschleger Eye Institute in a 4-year period was performed. Results: Sixty-three patients (35 men, mean age of 55 years) underwent trabeculectomy with brief exposure to MMC. Intraocular pressure (IOP) decreased a mean ± standard deviation of 17.9±9.6 mmHg from 30.4±9.5 mmHg preoperatively to 12.5±6.2 mmHg postoperatively after a mean follow up of 18.3 months (P<0.001). Number of antiglaucoma medications decreased from 2.9±1.1 preoperatively to 0.2±0.4 postoperatively (P<0.001, paired samples t-test). Complete success, defined as IOP< 18 mmHg without antiglaucoma medication, was achieved in 46 patients (73%) and qualified success, defined as IOP≤21 mmHg with or without antiglaucoma medications, was achieved in 59 patients (93.7%). Thirty-eight patients (60%) had a final IOP<15 mmHg with no glaucoma medications at the end of follow up. Needle revision was required in four patients (6.3%) and repeated trabeculectomy was performed in three patients (4.8%). Four patients had an IOP of less than 6mmHg at the end of follow-up period (three had final IOP of 5mmHg and one of 4mmHg); these patients had an average larger bleb size (2.8±1.3). Conclusions: Trabeculectomy with brief (15 s) exposure to MMC 0.4 mg/mL is safe and effective in lowering IOP in this group of patients, and results in low rate of postoperative complications. Success is comparable to reported data with longer exposure durations to antimetabolites.

Original languageEnglish
Pages (from-to)765-770
Number of pages6
JournalClinical and Experimental Ophthalmology
Issue number8
StatePublished - Nov 2006


  • Filtration surgery
  • Glaucoma surgery
  • Mitomycin C
  • Trabeculectomy


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