Abstract
Four new compounds of two unprecedented types, toxicols A-C (3-5) and toxiusol (8) have been isolated from the Red Sea sponge Toxiclona toxius. The four compounds are hexaprenoid hydroquinone sulfates consisting of two different polycyclic halves. The structure of all new compounds was determined mainly by 1D and 2D NMR measurements as well as some chemical transformations. Several of the new compounds were found in a preliminary study to inhibit the reverse transcriptase of human immuno deficiency virus (HIV) and to possess activity Candida albicans.
Original language | English |
---|---|
Pages (from-to) | 4275-4282 |
Number of pages | 8 |
Journal | Tetrahedron |
Volume | 49 |
Issue number | 20 |
DOIs | |
State | Published - 1993 |