Toxicols A-C and toxiusol - new bioactive hexaprenoid hydroquinones from Toxiclona toxius

Sara Isaacs, Amnon Hizi, Yoel Kashman

Research output: Contribution to journalArticlepeer-review

Abstract

Four new compounds of two unprecedented types, toxicols A-C (3-5) and toxiusol (8) have been isolated from the Red Sea sponge Toxiclona toxius. The four compounds are hexaprenoid hydroquinone sulfates consisting of two different polycyclic halves. The structure of all new compounds was determined mainly by 1D and 2D NMR measurements as well as some chemical transformations. Several of the new compounds were found in a preliminary study to inhibit the reverse transcriptase of human immuno deficiency virus (HIV) and to possess activity Candida albicans.

Original languageEnglish
Pages (from-to)4275-4282
Number of pages8
JournalTetrahedron
Volume49
Issue number20
DOIs
StatePublished - 1993

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