Toxicity and efficacy of autologous hematopoietic cell transplantation in elderly patients with aggressive lymphoma: a historical prospective study

Marina Davidov, Chava Perry, Yair Herishanu, Nadav Sarid, Esti Rom, Odelia Amit, Rinat Eshel, Ella Naparstek, Irit Avivi, Ron Ram

Research output: Contribution to journalArticlepeer-review

Abstract

High-dose therapy followed by autologous hematopoietic cell transplantation (HCT) prolongs overall survival in patients under 65 years old with relapsed aggressive lymphoma. We aimed to explore the toxicity and efficacy of HCT in patients over 65 years with aggressive lymphoma compared with younger patients. We compared the transplantation outcomes between patients ≥ 65 years (n = 58) and 55–64 years (n = 44) with chemosensitive aggressive lymphoma (DLBCL, MCL and TCL) that underwent HCT between 1999 and 2016 in the Tel-Aviv Medical Center. The median age was 68 (range, 65–74) and 61 (range, 55–64) years, respectively. There were no differences in the incidences of grade 3–4 mucositis, documented infections and pulmonary complications between the two groups. There was no difference in the incidences of secondary malignancies, relapse (p =.26), non-relapse mortality, (p =.77) and overall survival (p =.53). Multivariate analysis revealed that smoking was a risk factor for non-relapse mortality, while partial remission and > 2 lines of treatment prior HCT were associated with higher risk for relapse. Psycho-socioeconomic score was associated with prolonged hospitalization after HCT and recurrent hospitalizations. We conclude that patients ≥ 65 years old with aggressive lymphoma, compared to younger counterparts, have similar transplantation outcome. Improving habits and psychosocial factors may further improve outcomes in these patients.

Original languageEnglish
Pages (from-to)459-466
Number of pages8
JournalAnnals of Hematology
Volume97
Issue number3
DOIs
StatePublished - 1 Mar 2018

Keywords

  • Autologous hematopoietic cell transplantation
  • Elderly
  • Lymphoma

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