Towards computational prediction of microRNA function and activity

Igor Ulitsky*, Louise C. Laurent, Ron Shamir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


While it has been established that microRNAs (miRNAs) play key roles throughout development and are dysregulated in many human pathologies, the specific processes and pathways regulated by individual miRNAs are mostly unknown. Here, we use computational target predictions in order to automatically infer the processes affected by human miRNAs. Our approach improves upon standard statistical tools by addressing specific characteristics of miRNA regulation. Our analysis is based on a novel compendium of experimentally verified miRNA-pathway and miRNA-process associations that we constructed, which can be a useful resource by itself. Our method also predicts novel miRNA-regulated pathways, refines the annotation of miRNAs for which only crude functions are known, and assigns differential functions to miRNAs with closely related sequences. Applying our approach to groups of co-expressed genes allows us to identify miRNAs and genomic miRNA clusters with functional importance in specific stages of early human development. A full list of the predicted mRNA functions is available at

Original languageEnglish
Article numbergkq570
Pages (from-to)e160-e160
JournalNucleic Acids Research
Issue number15
StatePublished - 4 Feb 2010


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