Towards an adiposity-related disease framework for the diagnosis and management of obesities

Carolina M. Perdomo, Icíar Avilés-Olmos, Dror Dicker, Gema Frühbeck*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Obesity is a complex disease that relapses frequently and associates with multiple complications that comprise a worldwide health priority because of its rising prevalence and association with numerous complications, including metabolic disorders, mechanic pathologies, and cancer, among others. Noteworthy, excess adiposity is accompanied by chronic inflammation, oxidative stress, insulin resistance, and subsequent organ dysfunction. This dysfunctional adipose tissue is initially stored in the visceral depot, overflowing subsequently to produce lipotoxicity in ectopic depots like liver, heart, muscle, and pancreas, among others. People living with obesity need a diagnostic approach that considers an exhaustive pathophysiology and complications assessment. Thus, it is essential to warrant a holistic diagnosis and management that guarantees an adequate health status, and quality of life. The present review summarizes the different complications associated with obesity, at the same time, we aim to fostering a novel framework that enhances a patient-centered approach to obesity management in the precision medicine era.

Original languageEnglish
Pages (from-to)795-807
Number of pages13
JournalReviews in Endocrine and Metabolic Disorders
Issue number5
StatePublished - Oct 2023


  • Adiposity-based chronic disease
  • Adiposopathy
  • Cardiovascular disease
  • Obesity
  • Obesity-related adipose tissue disease
  • Visceral adipose tissue


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