Toward the synthesis of the rare N-(trifluoromethyl)amides and the N-(difluoromethylene)-N-(trifluoromethyl)amines [RN(CF3)CF 2R′] using BrF3

Youlia Hagooly, Julia Gatenyo, Aviv Hagooly, Shlomo Rozen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

(Chemical Equation Presented) A synthesis of a wide range of different aliphatic, aromatic, and heterocyclic N-(trifluoromethyl)-amides along with aromatic N-(difluoromethylene)-N-(trifluoromethyl)amine derivatives has been developed. The starting materials are the easily available isothiocyanates, and the fluorinating reagent is the commercially available bromine trifluoride. The reaction is performed under mild conditions, and the fluorinated amides and amines are produced in moderate to high yields.

Original languageEnglish
Pages (from-to)8578-8582
Number of pages5
JournalJournal of Organic Chemistry
Volume74
Issue number22
DOIs
StatePublished - 20 Nov 2009

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