Total leucoderma: A rare manifestation of cutaneous chronic graft-versus-host disease

A. Nagler; M. A. Goldenhersh; F. Levi-Schaffer; J. C. Bystryn; S. N. Klaus

doi:10.1111/j.1365-2133.1996.tb06991.x

Total leucoderma: A rare manifestation of cutaneous chronic graft-versus-host disease

A. Nagler^*
, M. A. Goldenhersh
, F. Levi-Schaffer
, J. C. Bystryn
, S. N. Klaus

^*Corresponding author for this work

Hadassah University Medical Centre
Kaplan Comprehensive Cancer Center

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

We describe a 14-year-old boy who developed total leucoderma during the course of chronic graft-versus-host disease, which developed after allogeneic bone marrow transplantation. Skin biopsy and dihydroxy-phenylalanine staining revealed a total absence of melanocytes from the epidermis. Cytotoxic anti-melanocyte antibodies were found in the patient's serum, and this probably explains the development of the leucoderma.

Original language	English
Pages (from-to)	780-783
Number of pages	4
Journal	British Journal of Dermatology
Volume	134
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2133.1996.tb06991.x
State	Published - 1996
Externally published	Yes

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10.1111/j.1365-2133.1996.tb06991.x

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abstract = "We describe a 14-year-old boy who developed total leucoderma during the course of chronic graft-versus-host disease, which developed after allogeneic bone marrow transplantation. Skin biopsy and dihydroxy-phenylalanine staining revealed a total absence of melanocytes from the epidermis. Cytotoxic anti-melanocyte antibodies were found in the patient's serum, and this probably explains the development of the leucoderma.",

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AB - We describe a 14-year-old boy who developed total leucoderma during the course of chronic graft-versus-host disease, which developed after allogeneic bone marrow transplantation. Skin biopsy and dihydroxy-phenylalanine staining revealed a total absence of melanocytes from the epidermis. Cytotoxic anti-melanocyte antibodies were found in the patient's serum, and this probably explains the development of the leucoderma.

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Total leucoderma: A rare manifestation of cutaneous chronic graft-versus-host disease

Abstract

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