TOR links starvation responses to telomere length maintenance

Martin Kupiec, Ronit Weisman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Telomeres are nucleoprotein structures that protect the ends of eukaryotic chromosomes and play important roles in ensuring the genome's integrity. Telomere length is maintained by complex mechanisms that ensure length homeostasis. Recent work has linked telomere length maintenance to the Tor protein kinases, which are central regulators of cellular growth. Here we summarize these results, which suggest a link between nutrient availability, telomere length maintenance and chronological lifespan.

Original languageEnglish
Pages (from-to)2268-2271
Number of pages4
JournalCell Cycle
Volume11
Issue number12
DOIs
StatePublished - 15 Jun 2012

Funding

FundersFunder number
Israel Cancer Research Fund
Association for International Cancer Research

    Keywords

    • Gln3
    • Saccharomyces cerevisiae
    • Schizosaccharomyces pombe
    • Starvation
    • TOR
    • Telomeres
    • Wtm1
    • Yku70
    • Yku80

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