Topical ophthalmic amethocaine alleviates trigeminal neuralgia pain

Silviu Brill*, Ron Ben-Abraham, Itay Goor-Aryeh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Trigeminal neuralgia (TGN) is a challenging pain syndrome. Aim: To test the effectiveness of local instillation of ophthalmic solution of amethocaine in relieving the pain of TGN. Methods: We performed an open-label prospective study in 40 consecutive currently treated patients suffering from TGN with a reported visual analog scale (VAS).8 (severe pain). The patients received two drops of amethocaine 1% instilled on the cornea ipsilateral to the painful side. Pain score assessment using VAS was recorded pre- and post-treatment. Results: A total of 32 (80%) patients reported a significant reduction in pain 10 minutes after drops instillation as compared with pre-treatment pain score. Pre-treatment VAS score was 8.53 ± 0.6 as compared with 4.78 ± 1.83 post-amethocaine treatments (P, 0.00001). Conclusion: Topical ophthalmic instillation of amethocaine 1% can be considered as an immediate effective method for pain paroxysm of TGN.

Original languageEnglish
Pages (from-to)155-157
Number of pages3
JournalLocal and Regional Anesthesia
Issue number1
StatePublished - 2010
Externally publishedYes


  • Amethocaine
  • Ophthalmic
  • Pain
  • Trigeminal neuralgia


Dive into the research topics of 'Topical ophthalmic amethocaine alleviates trigeminal neuralgia pain'. Together they form a unique fingerprint.

Cite this