Tolerance to experimental contact sensitivity induced by T cell vaccination

Yoseph A. Mekori, Nathan Karin, Giora Gottesman, Irun R. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

It was shown previously that experimental autoimmune diseases could be prevented or treated specifically by administering suitably attenuated autoimmune T lymphocytes to animals, a process termed T cell vaccination (Cohen, I. R., Sci. American 1988. 256: 52). We now report that T cell vaccination is an effective way of inducing tolerance to contact sensitivity to simple chemical haptens. Vaccines were prepared from populations of lymph node cells from specifically sensitized mice by activating the T cells with the T cell mitogen concanavalin A and then treating the T cell blasts with glutaraldehyde. The vaccinated mice showed decreased delayed sensitivity responses to the specific sensitizing antigen and developed significant delayed sensitivity responses to the T cells of the same specificity as those used for vaccination. Thus, T cell vaccination against contact sensitivity reactions appears to function similarly to T cell vaccination against autoimmune disease.

Original languageEnglish
Pages (from-to)2083-2087
Number of pages5
JournalEuropean Journal of Immunology
Volume20
Issue number9
DOIs
StatePublished - Sep 1990
Externally publishedYes

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