Tissues viability and blood flow sensing based on a new nanophotonics method

Inbar Yariv, Menashe Haddad, Hamootal Duadi, Menachem Motiei, Dror Fixler

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Extracting optical parameters of turbid medium (e.g. tissue) by light reflectance signals is of great interest and has many applications in the medical world, life science, material analysis and biomedical optics. The reemitted light from an irradiated tissue is affected by the light's interaction with the tissue components and contains the information about the tissue structure and physiological state. In this research we present a novel noninvasive nanophotonics technique, i.e., iterative multi-plane optical property extraction (IMOPE) based on reflectance measurements. The reflectance based IMOPE was applied for tissue viability examination, detection of gold nanorods (GNRs) within the blood circulation as well as blood flow detection using the GNRs presence within the blood vessels. The basics of the IMOPE combine a simple experimental setup for recording light intensity images with an iterative Gerchberg-Saxton (G-S) algorithm for reconstructing the reflected light phase and computing its standard deviation (STD). Changes in tissue composition affect its optical properties which results in changes in the light phase that can be measured by its STD. This work presents reflectance based IMOPE tissue viability examination, producing a decrease in the computed STD for older tissues, as well as investigating their organic material absorption capability. Finally, differentiation of the femoral vein from adjacent tissues using GNRs and the detection of their presence within blood circulation and tissues are also presented with high sensitivity (better than computed tomography) to low quantities of GNRs (<3 mg).

Original languageEnglish
Title of host publicationNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV
EditorsDan V. Nicolau, Alexander N. Cartwright, Dror Fixler
ISBN (Electronic)9781510614970
StatePublished - 2018
EventNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV 2018 - San Francisco, United States
Duration: 30 Jan 201831 Jan 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV 2018
Country/TerritoryUnited States
CitySan Francisco


  • Gerchberg-Saxton
  • blood vessel
  • gold nanorods
  • optical properties
  • tissue viability


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