Tissue irritating properties of bis-dequalinium acetate solutions for endodontic use

Larz Spangberg, Elizeu Alvaro Pascon, Arieh Y. Kaufman, Kamran Safavi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Bis-dequalinium acetate has been suggested as an endodontic antiseptic and irrigant because of its low surface tension and ability to aid in the removal of the smear layer formed during instrumentation. Recently, bis-dequalinium acetate for endodontic use was marketed as solvidont. In order to comprehensively assess its biological effect, the compound was tested for early tissue irritating effect through evaluation of enhanced vascular permeability. Various concentrations of the test substance were injected intradermally into the backs of rats and the capillary leakage was evaluated by spectroscopy. controls were 2% iodine-potassium iodide and 1% buffered sodium hypochlorite. Tissue reaction through intrabony implantation in the mandible of guinea pigs after observation periods of 4 and 12 wks was evaluated using the histological criteria outlined by the FDI Technical Report 9. Controls were the smooth surface of the carrier and polyethylene glycol. The results indicate that bis-dequalinium acetate causes only minor tissue irritation, has low toxicity, and compared with the reference medicaments may be a good alternative for clinical endodontics.

Original languageEnglish
Pages (from-to)88-97
Number of pages10
JournalJournal of Endodontics
Issue number2
StatePublished - Feb 1988


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