Tissue classification of noisy MR brain images using constrained GMM

Amit Ruf*, Hayit Greenspan, Jacob Goldberger

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present an automated algorithm for tissue segmentation of noisy, low contrast magnetic resonance (MR) images of the brain. We use a mixture model composed of a large number of Gaussians, with each brain tissue represented by a large number of the Gaussian components in order to capture the complex tissue spatial layout. The intensity of a tissue is considered a global feature and is incorporated into the model through parameter tying of all the related Gaussians. The EM algorithm is utilized to learn the parameter-tied Gaussian mixture model. A new initialization method is applied to guarantee the convergence of the EM algorithm to the global maximum likelihood. Segmentation of the brain image is achieved by the affiliation of each voxel to a selected tissue class. The presented algorithm is used to segment 3D, T1-weighted, simulated and real MR images of the brain into three different tissues, under varying noise conditions. Quantitative results are presented and compared with state-of-the-art results reported in the literature.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - 8th International Conference, Proceedings
Pages790-797
Number of pages8
DOIs
StatePublished - 2005
Event8th International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - Palm Springs, CA, United States
Duration: 26 Oct 200529 Oct 2005

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume3750 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference8th International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005
Country/TerritoryUnited States
CityPalm Springs, CA
Period26/10/0529/10/05

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