Timing of Implant Placement and Augmentation with Bone Replacement Material: Clinical Assessment at 8 and 16Months

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Purpose: The purpose of this study is to evaluate implants placed at different times of bone augmentation. Materials and Methods: Four implants were placed in seven dogs: one at a 6-month bovine mineral grafted site (6-month Bio-Oss® grafted site [6mBio]), one at a grafted membrane-protected simultaneously augmented (Fresh Bio-Oss® grafted site [FrBio]) site, one at a clotted (nongrafted clotted membrane-protected site [Clot]) membrane-protected site, and one at a pristine (nongrafted uncovered site [Cont]) site. Implants were exposed after 6months. The same protocol was repeated on the contralateral side, at a delay of 8months. Peri-implant care was performed throughout the hygienic phase (2 and 10months, respectively) every 48 to 72hours. Probing depth and bleeding on probing were recorded. Implant stability was determined by a Periotest® (Medizintechnik Gulden, Modautal, Germany). Statistical analysis was conducted using analysis of variance with repeated measures. Results: Average probing depth at the simultaneously grafted sites was 2.21mm and 2.03mm at 8 and 16months, respectively. At the 6-month grafted sites, it was 1.96mm and 1.57mm. At the Clot sites, it was 2.68mm and 2.07mm, and 2.21mm and 1.82mm at the Cont sites, respectively. The average bleeding on probing was 0.50 and 0.42 at the FrBio sites, and 0.35 and 0.07 at the 6mBio sites during the respective periods. At the Clot sites, it was 0.50 and 0.28, and at the Cont sites, 0.43 and 0.21, respectively. Probing depth significantly reduced over the time at 6mBio, Clot, and Cont sites (p<.03). Average implant stability score at the FrBio sites was -0.24 and -0.27, and -0.50 and -0.46 at the 6mBio sites, at 8 and 16months, respectively. At the Clot sites, it was -0.35 and -0.46. Cont sites averaged -0.37 at both periods. Implant stability was significantly higher (p<.005) comparing 6mBio over FrBio, 6mBio over Cont, and Clot over FrBio sites. Conclusions: Immediate and delayed augmentations are safe modes. Probing depth and bleeding indices gradually improved along time. Implant stability was higher at the delayed mode.

Original languageEnglish
Pages (from-to)121-129
Number of pages9
JournalClinical Implant Dentistry and Related Research
Issue number1
StatePublished - Feb 2013


  • Bone augmentation
  • Bone grafting
  • Bone replacement material
  • Bovine bone
  • Guided bone regeneration
  • Implant stability
  • Peri-implant healing
  • Periotest


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