Timing is critical: Gene, environment and timing interactions in genetics of suicide in children and adolescents

G. Zalsman*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

Abstract

Suicidal behavior runs in families and is prevalent in adolescence. Case-control and family-based studies in this age group failed to find a genetic association that survived replications. Gene environment approach gave new hope for possible associations especially with the short allele of the serotonin transporter promoter polymorphism (5-HTTLPR). However, a recent meta-analysis raised doubts about the consistency of these findings. Some new structural and functional imaging data may shade light on the age-related and gender-related development of the brain. This review suggests a new approach to gene by environment and timing interaction to understand the interplay that leads to suicidality in adolescents and young adults.

Original languageEnglish
Pages (from-to)284-286
Number of pages3
JournalEuropean Psychiatry
Volume25
Issue number5
DOIs
StatePublished - Jun 2010

Keywords

  • Adolescents
  • Gene environment interaction
  • Imaging
  • Polymorphism
  • Suicide
  • Timing

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