Time to first antibiotic dose for patients hospitalised with community-acquired pneumonia

Dafna Yahav*, Leonard Leibovici, Elad Goldberg, Jihad Bishara, Mical Paul

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

Abstract

Time to first antibiotic dose (TFAD) of 4 h or 8 h has been suggested as a quality measure for adult patients hospitalised with community-acquired pneumonia (CAP). Clinical evidence leading to implementation of this quality measure came from two large, retrospective studies. Following these studies, several prospective studies were conducted, with variable results. In a compilation of all observational studies to date, no significant benefit for short TFAD in terms of all-cause mortality was observed [unadjusted odds ratio (OR) = 1.01, 95% confidence interval (CI) 0.79-1.29, 13 studies; adjusted OR = 0.95, 95% CI 0.73-1.23, 14 studies]. Implementation of a requirement for short TFAD for CAP in the emergency department or other acute medical care setting may lead to unnecessary antibiotic treatment. We believe that attention should be shifted to early appropriate empirical antibiotic treatment for severe sepsis in hospital regardless of the source of infection, rather than focusing on CAP.

Original languageEnglish
Pages (from-to)410-413
Number of pages4
JournalInternational Journal of Antimicrobial Agents
Volume41
Issue number5
DOIs
StatePublished - May 2013

Keywords

  • Performance measures
  • Pneumonia
  • Time to antibiotic treatment

Fingerprint

Dive into the research topics of 'Time to first antibiotic dose for patients hospitalised with community-acquired pneumonia'. Together they form a unique fingerprint.

Cite this