TY - JOUR
T1 - Time-consuming procedures and prehospital thrombolytic treatment
AU - Roth, A.
AU - Hod, H.
AU - Miller, H. I.
AU - Glick, A.
AU - Shargorodski, B.
AU - Kaplinsky, E.
AU - Laniado, S.
PY - 1993
Y1 - 1993
N2 - Objectives: To assess time-consuming procedures in the prehospital stage of acute myocardial infarction patients who had received thrombolytic therapy at the scene, and to evaluate their effect on the clinical outcome. Design: Prospective study. Setting: Mobile intensive care unit staffed by an intern or a hospital-based physician. Participants and Interventions: Thrombolytic therapy with recombinant tissue-type plasminogen activator (total dose of 120 mg/6 hrs) was initiated at the scene in 167 patients. Treatment continued during transportation and thereafter in the cardiac care unit. During hospitalization, radionuclide ventriculograms and coronary angiography were performed in most patients. Measurements and Main Results: Correct diagnosis was confirmed in 165 of 167 patients. Mean time to treatment was 96±42 (SD) mins with no significant difference between patients treated at home (n = 105) or in public places (n = 60). Global duration of treatment was significantly shorter when thrombolytic therapy was given in public as compared with treatment applied at home (50 ± 13 vs. 57 ± 16 mins, respectively, p < .002). Conclusion: If patients and physicians become aware of the potential advantages of prompt initiation of thrombolytic therapy at the scene, critical time may be saved in delivering thrombolysis to the clotted coronary artery.
AB - Objectives: To assess time-consuming procedures in the prehospital stage of acute myocardial infarction patients who had received thrombolytic therapy at the scene, and to evaluate their effect on the clinical outcome. Design: Prospective study. Setting: Mobile intensive care unit staffed by an intern or a hospital-based physician. Participants and Interventions: Thrombolytic therapy with recombinant tissue-type plasminogen activator (total dose of 120 mg/6 hrs) was initiated at the scene in 167 patients. Treatment continued during transportation and thereafter in the cardiac care unit. During hospitalization, radionuclide ventriculograms and coronary angiography were performed in most patients. Measurements and Main Results: Correct diagnosis was confirmed in 165 of 167 patients. Mean time to treatment was 96±42 (SD) mins with no significant difference between patients treated at home (n = 105) or in public places (n = 60). Global duration of treatment was significantly shorter when thrombolytic therapy was given in public as compared with treatment applied at home (50 ± 13 vs. 57 ± 16 mins, respectively, p < .002). Conclusion: If patients and physicians become aware of the potential advantages of prompt initiation of thrombolytic therapy at the scene, critical time may be saved in delivering thrombolysis to the clotted coronary artery.
KW - cardiopulmonary emergencies
KW - coronary artery disease
KW - heart
KW - mobile emergency units
KW - myocardial infarction
KW - paramedics
KW - prehospital emergency care
KW - thrombolysis
KW - tissue-type plasminogen activators
UR - http://www.scopus.com/inward/record.url?scp=0027450764&partnerID=8YFLogxK
U2 - 10.1097/00003246-199303000-00014
DO - 10.1097/00003246-199303000-00014
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AN - SCOPUS:0027450764
SN - 0090-3493
VL - 21
SP - 374
EP - 379
JO - Critical Care Medicine
JF - Critical Care Medicine
IS - 3
ER -