TY - JOUR

T1 - Tilt modulus of a lipid monolayer

AU - May, S.

AU - Kozlovsky, Y.

AU - Ben-Shaul, A.

AU - Kozlov, M. M.

PY - 2004/7

Y1 - 2004/7

N2 - In addition to the familiar bending and stretching deformations, lipid monolayers and bilayers in their disordered state are often subjected to tilt deformations, occurring for instance in structural rearrangements accompanying membrane fusion, or upon insertion of "oblique" hydrophobic proteins into lipid bilayers. We study the elastic response of a flat lipid monolayer to a tilt deformation, using the spatial and conformational average of the chain end-to-end vector from the membrane normal to define a macroscopic membrane tilt. The physical origin and magnitude of the corresponding tilt modulus κt is analyzed using two complementary theoretical approaches. The first is a phenomenological model showing that the tilt and bending deformations are decoupled and the effects of inter-chain correlations on the tilt modulus is small. The second is based on a molecular-level mean-field theory of chain packing, enabling numerical evaluation of the tilt modulus for realistic, multi-conformation, chain models. Both approaches reveal that the tilt modulus involves two major contributions. The first is elastic in origin, arising from the stretching of the hydrocarbon chains upon a tilt deformation and reflecting the loss of chain conformational freedom associated with chain stretching. The second, purely entropic, contribution results from the constraints imposed by a tilt deformation on the fluctuations of chain director orientations. Using the chain-packing theory we compute the two contributions numerically as a function of the cross-sectional area per chain. The elastic and entropic terms are shown to dominate the value of κt for small and large areas per chain, respectively. For typical cross-sectional areas of lipid chains in biological membranes they areof comparable magnitude, yielding κt ≈ 0.2kBT/Å2.

AB - In addition to the familiar bending and stretching deformations, lipid monolayers and bilayers in their disordered state are often subjected to tilt deformations, occurring for instance in structural rearrangements accompanying membrane fusion, or upon insertion of "oblique" hydrophobic proteins into lipid bilayers. We study the elastic response of a flat lipid monolayer to a tilt deformation, using the spatial and conformational average of the chain end-to-end vector from the membrane normal to define a macroscopic membrane tilt. The physical origin and magnitude of the corresponding tilt modulus κt is analyzed using two complementary theoretical approaches. The first is a phenomenological model showing that the tilt and bending deformations are decoupled and the effects of inter-chain correlations on the tilt modulus is small. The second is based on a molecular-level mean-field theory of chain packing, enabling numerical evaluation of the tilt modulus for realistic, multi-conformation, chain models. Both approaches reveal that the tilt modulus involves two major contributions. The first is elastic in origin, arising from the stretching of the hydrocarbon chains upon a tilt deformation and reflecting the loss of chain conformational freedom associated with chain stretching. The second, purely entropic, contribution results from the constraints imposed by a tilt deformation on the fluctuations of chain director orientations. Using the chain-packing theory we compute the two contributions numerically as a function of the cross-sectional area per chain. The elastic and entropic terms are shown to dominate the value of κt for small and large areas per chain, respectively. For typical cross-sectional areas of lipid chains in biological membranes they areof comparable magnitude, yielding κt ≈ 0.2kBT/Å2.

UR - http://www.scopus.com/inward/record.url?scp=6344246038&partnerID=8YFLogxK

U2 - 10.1140/epje/i2004-10019-y

DO - 10.1140/epje/i2004-10019-y

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C2 - 15338441

AN - SCOPUS:6344246038

SN - 1292-8941

VL - 14

SP - 299

EP - 308

JO - European Physical Journal E

JF - European Physical Journal E

IS - 3

ER -