Thyroxine-induced redistribution of creatine kinase isoenzymes in rat cardiomyocyte cultures

H. Birk*, L. Alkaslassi, D. Harell, O. Sperling, A. Shainberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The present study demonstrates a change occurring in the creatine-kinase isoenzyme profile of cardiomyocyte cultures induced by a chronic administration of excessive amounts of thyroid hormones (TH). This change is manifested by an increased level of the CK-BB isoenzyme, generally at the expense of CK-MM isoenzyme. The elevation of CK-BB is probably a result of a specific effect of TH through activation of gene expression, rather than a contribution of an increased number of non-myocardial cells. The implications of these results in the diagnosis of heart failures are discussed.

Original languageEnglish
Pages (from-to)591-594
Number of pages4
Issue number6
StatePublished - Jun 1989
Externally publishedYes


  • Creatine-kinase isoenzymes
  • cardiomyocyte cultures
  • thyroid hormones


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