Thyroid hormones and cancer: Clinical studies of hypothyroidism in oncology

Aleck H. Hercbergs, Osnat Ashur-Fabian, David Garfield

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: To collect and assess clinical reports of a putative relationship between thyroid state and the biology of cancers of various types. Recent Findings: A number of prospective case-control studies reviewed here have suggested that subclinical hyperthyroidism increases risk of certain solid tumors and that spontaneous hypothyroidism may delay onset or reduce aggressiveness of cancers. Small case studies have reached similar conclusions. A controlled prospective trial of induced hypothyroidism beneficially affected the course of glioblastoma. A context in which to interpret such findings is the recent description of a plasma membrane receptor for thyroid hormone on cancer cells and dividing tumor-associated endothelial cells. Summary: Accumulating clinical evidence may justify new, broadly-based controlled studies in cancer patients of the possible contribution of thyroid hormone to tumor behavior.

Original languageEnglish
Pages (from-to)432-436
Number of pages5
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume17
Issue number5
DOIs
StatePublished - Oct 2010
Externally publishedYes

Keywords

  • cancer
  • hypothyroxinemia
  • integrin avb3
  • L-thyroxine
  • triiodothyronine

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