Thymic humoral factor-γ2 augments immune cell response and exerts antitumor activity in murine model systems

J. Beuth*, J. M. Schierholz, G. Mayer, Y. Keisari

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The immunomodulatory and antimetastatic/antitumor activity of thymic humoral factor-γ2 (THF-γ2) was evaluated in BALB/c-mice. Daily subcutaneous applications (7 consecutive days, 20, 200 ng of THF-γ2 per injection/mouse) upregulated counts of thymocytes and peripheral blood cells in tumor bearing mice. To check the influence of THF-γ2 treatment on the growth of experimental metastases, RAW 117 H10 lymphosarcoma cells or L-1 sarcoma cells were intravenously inoculated into BALB/c-mice to establish liver or lung metastases, respectively. Local tumor growth was induced by subcutaneous injection of L-1 sarcoma cells. THF-γ2 was subcutaneously administered daily for 7 consecutive days starting 24 hrs after tumor cell challenge. Organ colonization as well as local tumor growth were investigated on day 14 after tumor cell inoculation and demonstrated a statistically significant (p<0.05) reduction of experimental liver and lung metastases and local tumor growth for THF-γ2 treated mice.

Original languageEnglish
Pages (from-to)4473-4476
Number of pages4
JournalAnticancer Research
Volume20
Issue number6 B
StatePublished - 2000
Externally publishedYes

Keywords

  • Antimetastatic/antitumor activity
  • BALB/c-mice
  • Immuno-modulation
  • Thymic humoral factor-γ2

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