Abstract
The immunomodulatory and antimetastatic/antitumor activity of thymic humoral factor-γ2 (THF-γ2) was evaluated in BALB/c-mice. Daily subcutaneous applications (7 consecutive days, 20, 200 ng of THF-γ2 per injection/mouse) upregulated counts of thymocytes and peripheral blood cells in tumor bearing mice. To check the influence of THF-γ2 treatment on the growth of experimental metastases, RAW 117 H10 lymphosarcoma cells or L-1 sarcoma cells were intravenously inoculated into BALB/c-mice to establish liver or lung metastases, respectively. Local tumor growth was induced by subcutaneous injection of L-1 sarcoma cells. THF-γ2 was subcutaneously administered daily for 7 consecutive days starting 24 hrs after tumor cell challenge. Organ colonization as well as local tumor growth were investigated on day 14 after tumor cell inoculation and demonstrated a statistically significant (p<0.05) reduction of experimental liver and lung metastases and local tumor growth for THF-γ2 treated mice.
Original language | English |
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Pages (from-to) | 4473-4476 |
Number of pages | 4 |
Journal | Anticancer Research |
Volume | 20 |
Issue number | 6 B |
State | Published - 2000 |
Externally published | Yes |
Keywords
- Antimetastatic/antitumor activity
- BALB/c-mice
- Immuno-modulation
- Thymic humoral factor-γ2