Thrombotic thrombocytopenic purpura complicating chronic myelogenous leukemia treated with interferon-α

Rita Rachmani; Abraham Avigdor; Mona Youkla; Pia Raanani; Moshe Zilber; Mordchai Ravid; Isaac Ben-Bassat

doi:10.1159/000040905

Thrombotic thrombocytopenic purpura complicating chronic myelogenous leukemia treated with interferon-α

Rita Rachmani^*, Abraham Avigdor, Mona Youkla, Pia Raanani, Moshe Zilber, Mordchai Ravid, Isaac Ben-Bassat

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Two patients with chronic myelogenous leukemia are described in whom thrombotic thrombocytopenic purpura (TTP) developed following treatment by interferon-α. In one of the patients, a lymphoblastic transformation was diagnosed concomitantly. Prompt institution of plasmapheresis, steroids and vincristine resulted in complete resolution. In the hitherto reported case of TTP complicating interferon-α treated chronic myelogenous leukemia, the course was fatal.

Original language	English
Pages (from-to)	204-206
Number of pages	3
Journal	Acta Haematologica
Volume	100
Issue number	4
DOIs	https://doi.org/10.1159/000040905
State	Published - 1998

Keywords

Chronic myelogenous leukemia
Interferon
Plasmapheresis
Thrombotic thrombocytopenic purpura

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000040905

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title = "Thrombotic thrombocytopenic purpura complicating chronic myelogenous leukemia treated with interferon-α",

abstract = "Two patients with chronic myelogenous leukemia are described in whom thrombotic thrombocytopenic purpura (TTP) developed following treatment by interferon-α. In one of the patients, a lymphoblastic transformation was diagnosed concomitantly. Prompt institution of plasmapheresis, steroids and vincristine resulted in complete resolution. In the hitherto reported case of TTP complicating interferon-α treated chronic myelogenous leukemia, the course was fatal.",

keywords = "Chronic myelogenous leukemia, Interferon, Plasmapheresis, Thrombotic thrombocytopenic purpura",

author = "Rita Rachmani and Abraham Avigdor and Mona Youkla and Pia Raanani and Moshe Zilber and Mordchai Ravid and Isaac Ben-Bassat",

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T1 - Thrombotic thrombocytopenic purpura complicating chronic myelogenous leukemia treated with interferon-α

AU - Rachmani, Rita

AU - Avigdor, Abraham

AU - Youkla, Mona

AU - Raanani, Pia

AU - Zilber, Moshe

AU - Ravid, Mordchai

AU - Ben-Bassat, Isaac

PY - 1998

Y1 - 1998

N2 - Two patients with chronic myelogenous leukemia are described in whom thrombotic thrombocytopenic purpura (TTP) developed following treatment by interferon-α. In one of the patients, a lymphoblastic transformation was diagnosed concomitantly. Prompt institution of plasmapheresis, steroids and vincristine resulted in complete resolution. In the hitherto reported case of TTP complicating interferon-α treated chronic myelogenous leukemia, the course was fatal.

AB - Two patients with chronic myelogenous leukemia are described in whom thrombotic thrombocytopenic purpura (TTP) developed following treatment by interferon-α. In one of the patients, a lymphoblastic transformation was diagnosed concomitantly. Prompt institution of plasmapheresis, steroids and vincristine resulted in complete resolution. In the hitherto reported case of TTP complicating interferon-α treated chronic myelogenous leukemia, the course was fatal.

KW - Chronic myelogenous leukemia

KW - Interferon

KW - Plasmapheresis

KW - Thrombotic thrombocytopenic purpura

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JO - Acta Haematologica

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IS - 4

ER -

Thrombotic thrombocytopenic purpura complicating chronic myelogenous leukemia treated with interferon-α

Abstract

Keywords

UN SDGs

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