Thrombocytosis in the Offspring of Female Mice Receiving dl-Methadone

Y. Burstein, R. W. Grady, M. J. Kreek, A. R. Rausen, C. M. Peterson

Research output: Contribution to journalArticlepeer-review


Subcutaneous methadone administration (2.5 mg/kg/day) to female mice beginning 2 weeks prior to conception and continuing through weaning resulted in a significant increase in the number of circulating platelets (1650 × 103 vs 1150 × 103/mm3), an increase in marrow megakaryocytes per high power field (12.22 vs 9.59) and an increase in the percentage of young megakaryocytes (34.5 vs 28.4) in the offspring but not in the mothers. The effect was maximal 14 days after birth and diminished by 28 days. Injection of 5 mg/kg/day resulted in similar findings but the changes persisted for 35 days. These findings are consistent with those noted in the infants of human polydrug abusers and suggest that methadone plays a role in similar abnormalities in humans.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalExperimental Biology and Medicine
Issue number3
StatePublished - Jul 1980
Externally publishedYes


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