TY - JOUR
T1 - Thrombocytopenia Associated with Hypersensitivity to Ranitidine
T2 - Possible Cross‐Reactivity with Cimetidine
AU - Gafter, U.
AU - Zevin, D.
AU - Komlos, L.
AU - Livni, E.
AU - Levi, J.
PY - 1989/5
Y1 - 1989/5
N2 - A rare case of thrombocytopenia associated with ranitidine is described. The thrombocytopenia was accompanied by eosinophilia and slightly elevated serum IgE. The platelet and eosinophilic counts returned to normal as soon as the drug was stopped. Cell‐mediated immunity (CMI) determined in vitro by the leukocyte migration inhibition factor test was found against ranitidine and cimetidine. IgE antibody response against both drugs was also found by the mast cell degranulation test. These data suggest an association between the ranitidine‐induced thrombocytopenia and both humoral antibody response and CMI. Cross‐reactivity between the two H2‐receptor antagonists is suggested, as well.
AB - A rare case of thrombocytopenia associated with ranitidine is described. The thrombocytopenia was accompanied by eosinophilia and slightly elevated serum IgE. The platelet and eosinophilic counts returned to normal as soon as the drug was stopped. Cell‐mediated immunity (CMI) determined in vitro by the leukocyte migration inhibition factor test was found against ranitidine and cimetidine. IgE antibody response against both drugs was also found by the mast cell degranulation test. These data suggest an association between the ranitidine‐induced thrombocytopenia and both humoral antibody response and CMI. Cross‐reactivity between the two H2‐receptor antagonists is suggested, as well.
UR - http://www.scopus.com/inward/record.url?scp=0024373638&partnerID=8YFLogxK
U2 - 10.1111/j.1572-0241.1989.tb02584.x
DO - 10.1111/j.1572-0241.1989.tb02584.x
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AN - SCOPUS:0024373638
VL - 84
SP - 560
EP - 562
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
SN - 0002-9270
IS - 5
ER -