Thrombin inhibits the synthesis of prostanoids by isolated glomeruli and peritoneal macrophages in rats

E. Podjarny, M. Rathaus, A. Pomeranz, J. Shapira, J. Bernheim

Research output: Contribution to journalArticlepeer-review

Abstract

Activation of macrophages and release of mediators that activate the coagulation system characterize proliferative glomerulonephritis. To evaluate the possible role of prostanoids in this process, isolated rat glomeruli (G) and peritoneal macrophages (M) or a combination of the two (G + M) were incubated in the presence of thrombin (2 U/ml). In G, thrombin inhibited only the synthesis of thromboxane B2. In M and G + M incubations, the synthesis of prostaglandin I2 and thromboxane A2 was inhibited by thrombin. This effect was abolished by the addition of arachidonic acid. As prostanoids may play a modulatory role in the interaction between macrophages and glomerular cells, inhibition of their synthesis by thrombin might enhance macrophage activity.

Original languageEnglish
Pages (from-to)50-53
Number of pages4
JournalNephron
Volume53
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

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