Clinical and laboratory observations on a brother and sister with congenital hemorrhagic disorder are presented. Both had prolonged bleeding time, poor clot retraction and failure of the platelets to aggregate and adhere to glass in the presence of ADP, absence of platelet extractable fibrinogen and impairment of platelet factor 3 availability. The abnormal platelet function, confirms the recent diagnostic criteria of thrombasthenia. Coagulation studies in the parents were normal. The hemostatic abnormality in thrombasthenia is discussed.
|Number of pages||5|
|Journal||Acta Paediatrica, International Journal of Paediatrics|
|State||Published - Nov 1968|
- abnormal platelet function