Three novel protease inhibitors from a natural bloom of the cyanobacterium Microcystis aeruginosa

Alexei Ploutno, Maria Shoshan, Shmuel Carmeli

Research output: Contribution to journalArticlepeer-review

Abstract

Two new trypsin inhibitors, micropeptins EI992 (1) and EI964 (2), and a modified linear peptide aeruginosin EI461 (3) were isolated from the hydrophilic extract of two samples of Microcystis aeruginosa, collected from the Einan Reservoir in Israel: Homonuclear and heteronuclear. 2D-NMR techniques as well as HRFABMS determined the gross structures of 1-3. The relative and absolute stereochemistry of 1-3 was deduced by a combination of spectral data and Marfey's method for HPLC. Aeruginosin EI461 (3) differs from the 14 known aeruginosins in the relative and absolute stereochemistry of the Choi-6-hydroxyl substituent.

Original languageEnglish
Pages (from-to)973-978
Number of pages6
JournalJournal of Natural Products
Volume65
Issue number7
DOIs
StatePublished - 2002

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