Three novel protease inhibitors from a natural bloom of the cyanobacterium Microcystis aeruginosa

Alexei Ploutno; Maria Shoshan; Shmuel Carmeli

doi:10.1021/np010597b

Three novel protease inhibitors from a natural bloom of the cyanobacterium Microcystis aeruginosa

Alexei Ploutno, Maria Shoshan, Shmuel Carmeli

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Two new trypsin inhibitors, micropeptins EI992 (1) and EI964 (2), and a modified linear peptide aeruginosin EI461 (3) were isolated from the hydrophilic extract of two samples of Microcystis aeruginosa, collected from the Einan Reservoir in Israel: Homonuclear and heteronuclear. 2D-NMR techniques as well as HRFABMS determined the gross structures of 1-3. The relative and absolute stereochemistry of 1-3 was deduced by a combination of spectral data and Marfey's method for HPLC. Aeruginosin EI461 (3) differs from the 14 known aeruginosins in the relative and absolute stereochemistry of the Choi-6-hydroxyl substituent.

Original language	English
Pages (from-to)	973-978
Number of pages	6
Journal	Journal of Natural Products
Volume	65
Issue number	7
DOIs	https://doi.org/10.1021/np010597b
State	Published - 2002

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title = "Three novel protease inhibitors from a natural bloom of the cyanobacterium Microcystis aeruginosa",

abstract = "Two new trypsin inhibitors, micropeptins EI992 (1) and EI964 (2), and a modified linear peptide aeruginosin EI461 (3) were isolated from the hydrophilic extract of two samples of Microcystis aeruginosa, collected from the Einan Reservoir in Israel: Homonuclear and heteronuclear. 2D-NMR techniques as well as HRFABMS determined the gross structures of 1-3. The relative and absolute stereochemistry of 1-3 was deduced by a combination of spectral data and Marfey's method for HPLC. Aeruginosin EI461 (3) differs from the 14 known aeruginosins in the relative and absolute stereochemistry of the Choi-6-hydroxyl substituent.",

author = "Alexei Ploutno and Maria Shoshan and Shmuel Carmeli",

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doi = "10.1021/np010597b",

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AB - Two new trypsin inhibitors, micropeptins EI992 (1) and EI964 (2), and a modified linear peptide aeruginosin EI461 (3) were isolated from the hydrophilic extract of two samples of Microcystis aeruginosa, collected from the Einan Reservoir in Israel: Homonuclear and heteronuclear. 2D-NMR techniques as well as HRFABMS determined the gross structures of 1-3. The relative and absolute stereochemistry of 1-3 was deduced by a combination of spectral data and Marfey's method for HPLC. Aeruginosin EI461 (3) differs from the 14 known aeruginosins in the relative and absolute stereochemistry of the Choi-6-hydroxyl substituent.

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Three novel protease inhibitors from a natural bloom of the cyanobacterium Microcystis aeruginosa

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