TY - JOUR
T1 - Three new cyclic peroxides from the marine sponge Plakortis aff simplex
AU - Rudi, Amira
AU - Afanii, Rania
AU - Gravalos, Lola Garcia
AU - Aknin, Maurice
AU - Gaydou, Emile
AU - Vacelet, Jean
AU - Kashman, Yoel
PY - 2003/5/1
Y1 - 2003/5/1
N2 - In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH-EtOAc (1:1) extract of the sponge Plakortis aff simplex, collected in Madagascar, was found to be cytotoxic to a series of human tumor cells. From this sponge, three new compounds and one known one, two new 1,2-dioxane peroxylactones named plakortolides H (1) and I (2), and one new 1,2-dioxolane, designated andavadoic acid (3), have been isolated and their structures elucidated. In addition, the known N(3)- methyladenine (4) was isolated, to the best of our knowledge, for the first time from a marine source. Andavadoic acid (3) showed significant activity against 13 tumor cells with GI50 values in the submicromolar range.
AB - In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH-EtOAc (1:1) extract of the sponge Plakortis aff simplex, collected in Madagascar, was found to be cytotoxic to a series of human tumor cells. From this sponge, three new compounds and one known one, two new 1,2-dioxane peroxylactones named plakortolides H (1) and I (2), and one new 1,2-dioxolane, designated andavadoic acid (3), have been isolated and their structures elucidated. In addition, the known N(3)- methyladenine (4) was isolated, to the best of our knowledge, for the first time from a marine source. Andavadoic acid (3) showed significant activity against 13 tumor cells with GI50 values in the submicromolar range.
UR - http://www.scopus.com/inward/record.url?scp=0037513367&partnerID=8YFLogxK
U2 - 10.1021/np020589a
DO - 10.1021/np020589a
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AN - SCOPUS:0037513367
SN - 0163-3864
VL - 66
SP - 682
EP - 685
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 5
ER -