Three new cyclic peroxides from the marine sponge Plakortis aff simplex

Amira Rudi, Rania Afanii, Lola Garcia Gravalos, Maurice Aknin, Emile Gaydou, Jean Vacelet, Yoel Kashman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH-EtOAc (1:1) extract of the sponge Plakortis aff simplex, collected in Madagascar, was found to be cytotoxic to a series of human tumor cells. From this sponge, three new compounds and one known one, two new 1,2-dioxane peroxylactones named plakortolides H (1) and I (2), and one new 1,2-dioxolane, designated andavadoic acid (3), have been isolated and their structures elucidated. In addition, the known N(3)- methyladenine (4) was isolated, to the best of our knowledge, for the first time from a marine source. Andavadoic acid (3) showed significant activity against 13 tumor cells with GI50 values in the submicromolar range.

Original languageEnglish
Pages (from-to)682-685
Number of pages4
JournalJournal of Natural Products
Volume66
Issue number5
DOIs
StatePublished - 1 May 2003

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