Three-dimensional measurements of topographical changes in macular diseases using confocal laser tomography

D. Weinberger, H. Stiebel-Kalish, D. D. Gaton, M. Lusky, R. Axer-Siegel, E. Priel, Y. Yassur

Research output: Contribution to journalArticlepeer-review


Purpose: Confocal laser tomography permits the precise measurement of topographical changes which are often a result of macular diseases. This study describes and evaluates the topographical three-dimensional elevations and depressions present in macular holes and in central serous chorioretinopathy (CSC), and searches for a correlation between the various parameters obtained. Methods: Thirty-one eyes with full-thickness macular holes underwent scanning of their affected macula using the Heidelberg Retinal Tomograph (HRT). The following parameters were evaluated: area of the hole and its elevated rim, maximum depth of the hole, and maximum elevation of the elevated rim at 12, 3, 6, and 9 o'clock. In addition, 25 eyes with CSC underwent scanning of their macula with the HRT. The area, volume, maximum height and diameters of the sensory elevations were evaluated. Results: The average area of the macular holes was 0.33 mm2 and the rim area average was 2.99 mm2. The average area of the rim was found to be 9.06 times larger than that of the hole (p < 0.001). The depth of the hole averaged 144 μm. HRT measurements of the retinal elevation in eyes with CSC revealed that the mean area of elevation was 9.6 mm2 (2.7 -21.52, SD 5.22); the mean volume was 1.16 mm3 (0.11-4.73, SD 1.3); mean maximum height was 238 μm (97-450, SD 108); mean X axis was 3.4 mm (1.4 -5.6, SD 1.1); and mean Y axis was 3.03 mm (1.6-4.7, SD 0.98). Conclusions: The area of the rim of the macular holes was usually found to be larger than that of the hole, and in direct correlation to it. Also, the larger the hole area, the greater its depth. The average height in each of the four quadrants (12, 3, 6, and 9 o'clock) correlated with the other quadrant heights (p < 0.001). Most of the retinal elevations in larger CSC blebs were oval (X axis (horizontal) longer than Y axis (vertical)). The maximum height of the sensory elevations was found to be at the center of the dome in patients with smaller blebs (<5 mm2), and in the lower one-third of the dome in larger blebs (>5 mm2).

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalLasers and Light in Ophthalmology
Issue number1
StatePublished - 1997
Externally publishedYes


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