Three-dimensional genomic organization of genes’ function in eukaryotes

Alon Diament, Tamir Tuller*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


It is well known that in prokaryotes, genes are organized in transcription units called operons. Since each operon includes genes which are related to the same pathway, a relation between genomic proximity and functionality can be easily observed. In eukaryotes, usually there are no operons; however, in the last few decades, there have been growing evidence that the organization of eukaryotic genes is not random: Evolution shapes gene organization in eukaryotes in a way that will improve the organism’s fitness. In this chapter, we will review how previous studies in the field employed sophisticated experiments and analysis tools to decipher the way genes are organized in eukaryotic genomes.

Original languageEnglish
Title of host publicationEvolutionary Biology
Subtitle of host publicationConvergent Evolution, Evolution of Complex Traits, Concepts and Methods
PublisherSpringer International Publishing
Number of pages20
ISBN (Electronic)9783319413242
ISBN (Print)9783319413235
StatePublished - 1 Jan 2016


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