Three-Dimensional Cardiac Strain Imaging in Healthy Children Using RF-Data

Richard G.P. Lopata, Maartje M. Nillesen, Johan M. Thijssen, L. Kapusta, Chris L. De Korte

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, a new radio-frequency (RF)-based, three-dimensional (3-D) strain imaging technique is introduced and applied to 3-D full volume ultrasound data of the heart of healthy children. Continuing advances in performance of transducers for 3-D ultrasound imaging have boosted research on 3-D strain imaging. In general, speckle tracking techniques are used for strain imaging. RF-based strain imaging has the potential to yield better performance than speckle- based methods because of the availability of phase information but such a system output is commercially not available. Furthermore, the relatively low frame rate of 3-D ultrasound data has limited broad application of RF-based cardiac strain imaging. In this study, the previously reported two-dimensional (2-D) strain methodology was extended to the third dimension. Three-dimensional RF-data were acquired in 13 healthy children, in the age range of 6-15 years, at a relatively low frame rate of 38-51 Hz. A 3-D, free-shape, coarse-to-fine displacement and strain estimation algorithm was applied to the RF-data. The heart was segmented using 3-D ellipsoid fitting. Strain was estimated in the radial (R), circumferential (C) and longitudinal directions (L). Our preliminary results reveal the applicability of the 3-D strain estimation technique on full volume 3-D RF-data. The technique enabled 3-D strain imaging of all three strain components. The average strains for all children were in the lateral wall R = 37 ± 10% (infero-lateral) and R = 32% ± 10% (antero-lateral), C = -9% ± 4% (antero-lateral) and C = -9% ± 4% (infero-lateral), L = -18% ± 6 % (antero-lateral) and L = -15% ± 4% (infero-lateral). In the septum, strains were found to be R = 24% ± 10% (antero-septal) and R = 13% ± 5% (infero-septal), C = -13% ± 5% (antero-septal) and -13% ± 5% (infero-septal) and L = -13% ± 3% (antero-septal) and L = -16% ± 5% (infero-septal). Strain in the anterior and inferior walls seemed underestimated, probably caused by the low (in-plane) resolution and poor image quality. The field-of-view as well as image quality were not always sufficient to image the entire left ventricle. It is concluded that 3-D strain imaging using RF-data is feasible, but validation with other modalities and with conventional 3-D speckle tracking techniques will be necessary.

Original languageEnglish
Pages (from-to)1399-1408
Number of pages10
JournalUltrasound in Medicine and Biology
Volume37
Issue number9
DOIs
StatePublished - Sep 2011
Externally publishedYes

Keywords

  • 3-D strain estimation
  • Cardiac strain
  • Children
  • Echocardiography
  • Elastography
  • In vivo
  • Ultrasound

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