Three apparent receptor subtypes for the endothelin/sarafotoxin family

Y. Kloog; D. Bousso-Mittler; A. Bdolah; M. Sokolovsky

doi:10.1016/0014-5793(89)80958-5

Three apparent receptor subtypes for the endothelin/sarafotoxin family

Y. Kloog, D. Bousso-Mittler, A. Bdolah, M. Sokolovsky^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

Competition binding experiments performed with ¹²⁵I-sarafotoxin (SRTX)-b and SRTX-b, SRTX-c and endothelin (ET-1 and ET-3) using homogenates of rat right and left atria, aorta, uterus, cerebellum and caudate putamen indicated heterogeneity of the ET/SRTX receptor. The evidence pointed to the existence of three receptor subtypes: a high-affinity ET-1/SRTX-b subtype typical of smooth muscle (E-S_α receptor), a high-affinity SRTX-c subtype typical of the cerebellum (E-S_β receptor), and a less selective subtype typical of the caudate putamen that binds all of these peptides with high affinity (E-S_γ receptor).

Original language	English
Pages (from-to)	199-202
Number of pages	4
Journal	FEBS Letters
Volume	253
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(89)80958-5
State	Published - 14 Aug 1989

Keywords

(Rat, Brain, Aorta, Heart, Uterus)
Endothelin
Receptor subtype
Sarafotoxin

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10.1016/0014-5793(89)80958-5

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title = "Three apparent receptor subtypes for the endothelin/sarafotoxin family",

abstract = "Competition binding experiments performed with 125I-sarafotoxin (SRTX)-b and SRTX-b, SRTX-c and endothelin (ET-1 and ET-3) using homogenates of rat right and left atria, aorta, uterus, cerebellum and caudate putamen indicated heterogeneity of the ET/SRTX receptor. The evidence pointed to the existence of three receptor subtypes: a high-affinity ET-1/SRTX-b subtype typical of smooth muscle (E-Sα receptor), a high-affinity SRTX-c subtype typical of the cerebellum (E-Sβ receptor), and a less selective subtype typical of the caudate putamen that binds all of these peptides with high affinity (E-Sγ receptor).",

keywords = "(Rat, Brain, Aorta, Heart, Uterus), Endothelin, Receptor subtype, Sarafotoxin",

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AU - Kloog, Y.

AU - Bousso-Mittler, D.

AU - Bdolah, A.

AU - Sokolovsky, M.

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AB - Competition binding experiments performed with 125I-sarafotoxin (SRTX)-b and SRTX-b, SRTX-c and endothelin (ET-1 and ET-3) using homogenates of rat right and left atria, aorta, uterus, cerebellum and caudate putamen indicated heterogeneity of the ET/SRTX receptor. The evidence pointed to the existence of three receptor subtypes: a high-affinity ET-1/SRTX-b subtype typical of smooth muscle (E-Sα receptor), a high-affinity SRTX-c subtype typical of the cerebellum (E-Sβ receptor), and a less selective subtype typical of the caudate putamen that binds all of these peptides with high affinity (E-Sγ receptor).

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Three apparent receptor subtypes for the endothelin/sarafotoxin family

Abstract

Keywords

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