Three apparent receptor subtypes for the endothelin/sarafotoxin family

Y. Kloog, D. Bousso-Mittler, A. Bdolah, M. Sokolovsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Competition binding experiments performed with 125I-sarafotoxin (SRTX)-b and SRTX-b, SRTX-c and endothelin (ET-1 and ET-3) using homogenates of rat right and left atria, aorta, uterus, cerebellum and caudate putamen indicated heterogeneity of the ET/SRTX receptor. The evidence pointed to the existence of three receptor subtypes: a high-affinity ET-1/SRTX-b subtype typical of smooth muscle (E-Sα receptor), a high-affinity SRTX-c subtype typical of the cerebellum (E-Sβ receptor), and a less selective subtype typical of the caudate putamen that binds all of these peptides with high affinity (E-Sγ receptor).

Original languageEnglish
Pages (from-to)199-202
Number of pages4
JournalFEBS Letters
Volume253
Issue number1-2
DOIs
StatePublished - 14 Aug 1989

Keywords

  • (Rat, Brain, Aorta, Heart, Uterus)
  • Endothelin
  • Receptor subtype
  • Sarafotoxin

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