TY - JOUR
T1 - Thoracic Duct Narrowing—Innovative Technique Restraining Weight Gain in Rats
AU - Rosenzweig, Barak
AU - Barshack, Iris
AU - Harats, Dror
AU - Shaish, Aviv
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Background: The lymphatic system is responsible for the absorption of fats from the digestive system, conveying 60–70 % of ingested fat to the blood stream. From the anatomical point of view, all the lymphatic drainage from the lower half of the body converges in the abdomen to enter the thoracic duct. This experimental study aim was to study the result of thoracic duct narrowing (TDN), an innovative surgical technique, on weight gain restrain in high-fat diet-fed rats. Methods: Forty-seven rats were allocated into three groups: thoracic duct narrowing (“S”—surgery), sham operation (“CS”—control surgery), and no surgery (“C”—control). All rats were fed with high-fat, cholesterol-rich diet. Food consumption and metabolic syndrome parameters including weight gain, plasma lipids and glucose, blood pressure, and viscera weight and histopathology were analyzed. Results: Thoracic duct narrowing was proved simple and safe surgical procedure in the rat model. TDN induced weight gain restrain, associated with mild hepatic steatosis compared to moderate-severe hepatic steatosis in control groups. Splenomegaly and splenic fatty histiocytes were shown in the treated animals. Conclusions: TDN improved several parameters of the metabolic syndrome in high-fat diet-fed rats. TDN carries the potential of innovative obesity treatment using the lymphatic route of lipid absorption.
AB - Background: The lymphatic system is responsible for the absorption of fats from the digestive system, conveying 60–70 % of ingested fat to the blood stream. From the anatomical point of view, all the lymphatic drainage from the lower half of the body converges in the abdomen to enter the thoracic duct. This experimental study aim was to study the result of thoracic duct narrowing (TDN), an innovative surgical technique, on weight gain restrain in high-fat diet-fed rats. Methods: Forty-seven rats were allocated into three groups: thoracic duct narrowing (“S”—surgery), sham operation (“CS”—control surgery), and no surgery (“C”—control). All rats were fed with high-fat, cholesterol-rich diet. Food consumption and metabolic syndrome parameters including weight gain, plasma lipids and glucose, blood pressure, and viscera weight and histopathology were analyzed. Results: Thoracic duct narrowing was proved simple and safe surgical procedure in the rat model. TDN induced weight gain restrain, associated with mild hepatic steatosis compared to moderate-severe hepatic steatosis in control groups. Splenomegaly and splenic fatty histiocytes were shown in the treated animals. Conclusions: TDN improved several parameters of the metabolic syndrome in high-fat diet-fed rats. TDN carries the potential of innovative obesity treatment using the lymphatic route of lipid absorption.
KW - Hepatic steatosis
KW - Splenic fatty histiocytes
KW - Thoracic duct
KW - Weight gain
KW - Weight reduction
UR - http://www.scopus.com/inward/record.url?scp=84947484377&partnerID=8YFLogxK
U2 - 10.1007/s11695-015-1917-y
DO - 10.1007/s11695-015-1917-y
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C2 - 26446490
AN - SCOPUS:84947484377
SN - 0960-8923
VL - 25
SP - 2443
EP - 2450
JO - Obesity Surgery
JF - Obesity Surgery
IS - 12
ER -