TY - JOUR
T1 - Third ventricle enlargement among newborn infants with trisomy 21
AU - Schimmel, Michael S.
AU - Hammerman, Cathy
AU - Bromiker, Ruben
AU - Berger, Itai
PY - 2006/5
Y1 - 2006/5
N2 - OBJECTIVE. Our goal was to determine whether the third ventricle is significantly enlarged among neonates with trisomy 21, compared with infants without clinical signs of trisomy 21. This enlargement might be related to hypoplasia of the structures surrounding the third ventricle. These structures participate in cognitive development, and hypoplasia in this area may be responsible for some of the unique cognitive abnormalities observed among children with trisomy 21. METHODS. Measurements of routine head sonographic scans of 57 term infants with trisomy 21 who were born between January 2000 and August 2005 were performed within 7 days after birth and were compared with measurements of head sonographic scans of 21 randomly selected, healthy, term infants without trisomy 21. RESULTS. Although the 2 groups were of similar gestational ages, infants with trisomy 21 were generally smaller, with smaller head circumferences. Despite the smaller overall head circumference, both the width and length of the third ventricle were enlarged among the infants with trisomy 21. Vertical measurements of the lateral ventricles were similar for the 2 groups. CONCLUSIONS. The third ventricle is an important diencephalic space. In our neonatal population, we did show significant enlargement of both the length and width of the third ventricle among the infants with trisomy 21, compared with the control group of unaffected newborns. We suspect that the unique neuropsychological development and cognitive dysfunction associated with trisomy 21 and the enlargement of the third ventricle in the neonatal period might be related.
AB - OBJECTIVE. Our goal was to determine whether the third ventricle is significantly enlarged among neonates with trisomy 21, compared with infants without clinical signs of trisomy 21. This enlargement might be related to hypoplasia of the structures surrounding the third ventricle. These structures participate in cognitive development, and hypoplasia in this area may be responsible for some of the unique cognitive abnormalities observed among children with trisomy 21. METHODS. Measurements of routine head sonographic scans of 57 term infants with trisomy 21 who were born between January 2000 and August 2005 were performed within 7 days after birth and were compared with measurements of head sonographic scans of 21 randomly selected, healthy, term infants without trisomy 21. RESULTS. Although the 2 groups were of similar gestational ages, infants with trisomy 21 were generally smaller, with smaller head circumferences. Despite the smaller overall head circumference, both the width and length of the third ventricle were enlarged among the infants with trisomy 21. Vertical measurements of the lateral ventricles were similar for the 2 groups. CONCLUSIONS. The third ventricle is an important diencephalic space. In our neonatal population, we did show significant enlargement of both the length and width of the third ventricle among the infants with trisomy 21, compared with the control group of unaffected newborns. We suspect that the unique neuropsychological development and cognitive dysfunction associated with trisomy 21 and the enlargement of the third ventricle in the neonatal period might be related.
KW - Down syndrome
KW - Neurodevelopment
KW - Third ventricle
KW - Trisomy 21
UR - http://www.scopus.com/inward/record.url?scp=33646852212&partnerID=8YFLogxK
U2 - 10.1542/peds.2005-1788
DO - 10.1542/peds.2005-1788
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C2 - 16651295
AN - SCOPUS:33646852212
SN - 0031-4005
VL - 117
SP - e928-e931
JO - Pediatrics
JF - Pediatrics
IS - 5
ER -