Thick fetal corpus callosum: An ominous sign?

T. Lerman-Sagie*, L. Ben-Sira, R. Achiron, L. Schreiber, G. Hermann, D. Lev, D. Kidron, G. Malinger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: Anomalies of the corpus callosum are frequently diagnosed during pregnancy, but a thick corpus callosum is a rare finding and its significance is not clear. We aimed to assess the significance of thick fetal corpus callosum by reviewing our experience of such cases. Methods: The records of all fetuses with anomalies of the corpus callosum referred to the prenatal diagnosis units of two university hospitals from 2000 to 2007 were reviewed. Nine fetuses with a thick corpus callosum were identified. Results: In all cases there were associated abnormalities: macrocephaly, ventriculomegaly, vermian agenesis, abnormal sulcation or encephalocele. Four pregnancies were terminated and in each of these cases the autopsy confirmed dysmorphic features and additional brain abnormalities. Five infants were delivered; two died shortly after birth, one suffers from mental retardation, one had neonatal convulsions and one is developing normally. Conclusions: A thick fetal corpus callosum is usually associated with other brain anomalies and is part of a neurogenetic syndrome in most cases.

Original languageEnglish
Pages (from-to)55-61
Number of pages7
JournalUltrasound in Obstetrics and Gynecology
Issue number1
StatePublished - Jul 2009


  • Corpus callosum
  • Fetal brain
  • MRI
  • Prenatal diagnosis
  • Ultrasound


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