Therapeutic plasma exchange for neonatal hepatic failure

Aviv Sever*, Jerry Stein, Alon Kalo, Michal Pearl-Yafe, Gili Kadmon, Avichai Weissbach, Elhanan Nahum, Eytan Kaplan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We report a case of therapeutic plasma exchange in a neonate with fulminant liver failure. A six-day old, 2800-gram baby was referred to our medical center for evaluation and treatment of fulminant hepatic failure. The working diagnosis at admission was gestational alloimmune liver disease, and therapeutic plasma exchange was proposed. A double volume plasma exchange was successfully performed, using the Spectra Optia apheresis system, primed with packed red blood cells. Access was obtained via a radial artery catheter and a peripheral intravenous line. On hospital D-14 a diagnosis of E3 deficiency was confirmed, and disease-specific therapy was started. Automated TPE using peripheral arterial and venous catheters may be safely performed in neonates, and should be considered in the treatment of a variety of disorders including neonatal fulminant hepatic failure.

Original languageEnglish
Article number103810
JournalTransfusion and Apheresis Science
Issue number6
StatePublished - Dec 2023


  • E3 deficiency
  • Gestational alloimmune liver disease
  • Liver failure
  • Plasma exchange
  • Spectra optia


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