Therapeutic effect of colloid bismuth subcitrate in experimental colitis in the rat

I. Zahavi, Z. Burg, H. Marcus, F. Kanneli, M. Nusinovitz, G. Dinari

Research output: Contribution to journalArticlepeer-review

Abstract

Colloid bismuth subcitrate (CBS) has a protective effect on ulcerated gastric and duodenal mucosa. To investigate its effect on large intestinal mucosal injury, we used acetic acid-induced colitis in the rat. Colitis was produced in male Wistarrats by rectal instillation of 1 nil of 10% acetic acid followed immediately by 1.5 ml of NaCl 0.9% (saline) enema. 1.5 ml of saline containing 240 mg of CBS or saline alone were then administered rectally every 24 h for 5 days. Another group of animals received CBS only. On the sixth day the distal colon was examined macroscopically and histologically using a 0 (nor mal) to 3 (necrosis) score. Prostaglandin E2 (PGE2) was measured by RIA (ng/mg protein). CBS significantly reduced both macroscopic and microscopic scores from 2.09 to 1.25 (p< 0.02) and from 2.4 to 1.08 (p<0.02) respectively. It also induced a significant reduction in PGE2 from 1.6 to 0.57 (p < 0.004) in the inflamed colonic mucosa. The significant protective effect of topical CBS, which is accompanied by a reduction of PGE2, indicates that CBS may have a role in the treatment of colitis.

Original languageEnglish
Pages (from-to)211-213
Number of pages3
JournalDigestion
Volume56
Issue number3
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • Colloid bismuth subcitrate
  • De-Nol
  • Experimental colitis
  • Prostaglandin E<inf>2</inf>
  • Rat

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