Therapeutic drug monitoring in inflammatory bowel disease

Uri Kopylov*, Shomron Ben-Horin, Ernest Seidman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Tumor necrosis factor (TNF)-α inhibitors and thiopurines are among the most important classes of medications utilized in the clinical management of Crohn’s disease and ulcerative colitis. A significant proportion of patients loses response to these agents or develops adverse effects during the course of the treatment. Monitoring of drug levels and anti-drug antibodies (for TNF-α inhibitors) and metabolite levels (for thiopurines) can provide valuable insight into the possible etiology of unfavorable outcomes and allow for an appropriate management strategy for these patients. This review summarizes the current knowledge on the clinical implications of therapeutic drug monitoring in inflammatory bowel disease patients treated with TNF-α inhibitors and thiopurines.

Original languageEnglish
Pages (from-to)304-312
Number of pages9
JournalAnnals of Gastroenterology
Volume27
Issue number4
StatePublished - 2014

Keywords

  • Biologics
  • Crohn’s disease
  • Inflammatory bowel disease
  • Thiopurines
  • Ulcerative colitis

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