Therapeutic approach to childhood hypercholesterolemia

Raanan Shamir*, Jonathan E. Feig, Edward A. Fisher

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Hypercholesterolemia is associated with increased risk of premature cardiovascular disease in adults, while early atherosclerotic lesions (reversible fatty streaks and non reversible fibrous plaques) are also associated with cardiovascular risk factors including low density lipoprotein-cholesterol (LDL-C). Although LDL-C is a risk factor that should be addressed in high risk children such as those with familial hypercholesterolemia, it is unclear, at present, whether there is a certain plasma LDL-C level that would call for an intervention regardless of the etiology of elevated LDL-C. Therefore, at present, screening the entire population to identify subjects with hypercholesterolemia is not justified. The aims of this review are to familiarize the reader with inherited diseases that are associated with elevated LDL-C and discuss the management of children with elevated LDL-C.

Original languageEnglish
Pages (from-to)649-655
Number of pages7
JournalPediatric Endocrinology Reviews
Issue number2
StatePublished - Dec 2007
Externally publishedYes


  • Children
  • Hypercholesterolemia
  • Low Density Lipoprotein-Cholesterol (LDL-C)
  • Treatment


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